Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model

Mardani Abdul Halim and Izzah Madihah Rosli and Siti Shafika Muhammad Jaafar and Ooi,, Hoi Min and Leong, Pui Wei and Shaharum Shamsuddin and Nazalam Najimudin and Ghows Azzam (2024) Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model. Asia-Pacific Journal of Molecular Biology and Biotechnology, 32. pp. 66-70. ISSN 0128-7451

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URL: https://www.biorxiv.org/content/10.1101/2020.04.27...

Abstract

Alzheimer’s disease is a complex neurodegenerative disease and is only unique to human. The disease is defined in human brain by the accumulation of amyloid beta in the parenchyma of the brain. Withania somnifera, commonly known as Ashwagandha is an Indian Ayurvedic medicine that has been used for centuries to treat countless range of human health problem. The active compound of Ashwagandha was shown to be beneficial in treating many neurodegenerative diseases including Alzheimer’s disease (AD). In this study, Drosophila melanogaster AD model was used to study the effect of Ashwagandha on the toxicity of beta amyloid and also the longevity effect of the compound. We found that 20 mg/mL of Ashwagandha was shown to be effective in rescuing the “rough eye phenotype” of AD Drosophila. Furthermore, Ashwagandha also promotes longevity in AD as well as wild type Drosophila. The results above showed that Ashwagandha could potentially be a potent drug to treat AD as well as maintaining the wellbeing of cells.

Item Type:	Article
Keyword:	Ageing, Withania somnifera, Alzheimer’s disease, Drosophila melanogaster, longevity
Subjects:	Q Science > QH Natural history > QH301-705.5 Biology (General) > QH426-470 Genetics R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	Nurul Fazira
Date Deposited:	09 Sep 2024 15:54
Last Modified:	09 Sep 2024 15:54
URI:	https://eprints.ums.edu.my/id/eprint/40907

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