Predictive factors for diabetes mellitus: insights from complete blood count analysis

Agnes Ayang Kenyang and Nurliyana Juhan and Yong Zulina Zubairi and Nornazirah Azizan and Ho Chong Mun (2024) Predictive factors for diabetes mellitus: insights from complete blood count analysis. Sains Malaysiana, 53 (10). pp. 1-9. ISSN 0126-6039

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Abstract

The 10th edition of the International Diabetes Federation reports that 537 million people worldwide had diabetes in 2021. In Southeast Asia, countries like Malaysia are facing a growing burden of diabetes. This highlights the urgent need for innovative and resourceful approaches to diabetes management. As the prevalence of diabetes continues to rise in these countries, tailored strategies are necessary. To identify and evaluate the potential prognostic indicators for diabetes mellitus, this study involved a dataset consisting of 500 entries, comprising demographic information and selected blood cells from the Complete Blood Count (CBC) test results obtained from the Clinical Laboratory Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah. Using univariate and multivariate logistic regression analysis, the prognostic predictors for diabetes mellitus were identified. In the univariate analysis, all variables are statistically significance at 5% level of significance. However, at multivariate analysis, only age, mean corpuscular hemoglobin concentration (MCHC), white blood cells (WBC) and hematocrit (HCT) emerged as significant predictors of diabetes mellitus. Notably, the abnormal level in WBC exhibited the greatest association with diabetes mellitus, reflecting a 114.7% increased risk compared to a normal WBC level. The statistic value obtained from Hosmer-Lemeshow was 0.944 indicating a well-fitting model. Additionally, the receiver operator characteristic (ROC) curve has a value of 0.7, indicating a strong performance of the model. In conclusion, CBC parameters can be accurate markers and useful in assisting clinical decision-making when properly applied and interpreted

Item Type:	Article
Keyword:	Complete Blood Count (CBC); diabetes mellitus; prognosis; regression analysis
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC648-665 Diseases of the endocrine glands. Clinical endocrinology
Department:	FACULTY > Faculty of Science and Natural Resources
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	07 Mar 2025 11:30
Last Modified:	07 Mar 2025 11:30
URI:	https://eprints.ums.edu.my/id/eprint/43076

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