Menopausal hormonal therapy and ovarian cancer—an update: a literature review

Mohsen MA Abdelhafez and Karim AM Ahmed and Nashwa AM Ahmed and Mohd Hamdy Ismail and Mohd Nazri Bin Mohd Daud and Ayaa M Eldisty and Mohd Fariz Bin Amri and Mohammad Saffree Jeffree and Fairrul Kadir and Dg Marshitah Pg Baharuddin and Mohammed Firdaus Bin Bolong and Firdaus Hayati and Nornazirah Bt Azizan and Doreen Sumpat and Syed Sharizman Syed Abdul Rahim and Win W Than and Zhen, Zhen Lo and May, Zaw Soe (2025) Menopausal hormonal therapy and ovarian cancer—an update: a literature review. Journal of South Asian Federation of Obstetrics and Gynaecology, 17. pp. 131-135. ISSN 0974-8938

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Abstract

Menopausal hormone replacement therapy (MHT/HT) was the recommended course of treatment for regulating menopause before 2002 when publishing the Women’s Health Initiative (WHI). Menopausal hormone replacement therapy (MHT/HT) and the WHI were the recommended courses of treatment for regulating menopause before 2002. This study aims to evaluate previous studies looking at the connection between MHT consumption and ovarian cancer risk and subanalyze the magnitude of this risk (if any) according to the type of hormone used and other confounders. A systematic search was accomplished through medical databases such as PubMed, Medline, Google Scholar, Web of Science, and others to gather the most recent and relevant articles investigating the issue to build up a body of evidence-based recommendations and guidelines required by women’s carers to counsel and prescribe MHT for postmenopausal women who opted to use these medications. The study concluded that, following the publishing of the outcomes of WHI trials, many countries had seen a dramatic decrease in MHT prescription because of raised suspicions of increased risks of developing gynecological cancers associated with its use. The major worries were linked to breast and ovarian cancers as well as endometrial cancer for unopposed estrogen therapy users.

Item Type:	Article
Keyword:	Combined estrogen–progestogen therapy, Menopause: estrogen–progestogen, Menopausal hormone therapy, Ovarian cancer
Subjects:	R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	29 Apr 2025 11:14
Last Modified:	29 Apr 2025 11:14
URI:	https://eprints.ums.edu.my/id/eprint/43644

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