Roles of prostaglandins and cyclooxygenases in autism spectrum disorder: a comprehensive review

Datu Agasi Mohd Kamal and Shahidee Zainal Abidin and Wan Salman Wan Saudi and Jaya Kumar and Alessio Bellato (2025) Roles of prostaglandins and cyclooxygenases in autism spectrum disorder: a comprehensive review. Current Behavioral Neuroscience Reports, 12 (2). pp. 1-15.

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Abstract

Purpose of Review Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with multifaceted etiologies. Emerging evidence implicates dysregulation of prostaglandins and cyclooxygenase (COX) enzymes in ASD pathophysiology. This review aims to explore key mechanisms through which prostaglandins and COX enzymes may influence ASD. Recent Findings Recent research highlights significant roles for prostaglandins and COX enzymes in modulating Wnt (Wingless and Int-1) signalling pathways, which are known autism susceptibility pathways, as well as in regulating dendritic arborisation and cerebellar function. Polymorphisms in COX genes have also been linked to ASD, indicating a genetic component to this dysregulation. Furthermore, prostaglandins and COX enzymes show potential as biomarkers for ASD. Summary The accumulated evidence underscores the involvement of prostaglandins and COX enzymes in ASD pathophysiology. This insight offers a deeper understanding of the disorder and may pave the way for more effective diagnostic and treatment strategies.

Item Type:	Article
Keyword:	Autism spectrum disorder, Prostaglandins, Cyclooxygenases, Neurodevelopment, Neuroinflammation, COX polymorphisms, Wnt pathway
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders > RC435-571 Psychiatry > RC512-569.5 Psychopathology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	02 May 2025 11:21
Last Modified:	02 May 2025 11:21
URI:	https://eprints.ums.edu.my/id/eprint/43722

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