Morinda citrifolia L. (Noni) fruits: Optimising extraction kinetics of yield and flavonoids for enhanced antioxidant activity at different temperatures

Tun Faiz Al Hakim Tun Faisal Ismail and Mohammad Amil Zulhilmi Benjamin and Mohd Azrie Awang (2024) Morinda citrifolia L. (Noni) fruits: Optimising extraction kinetics of yield and flavonoids for enhanced antioxidant activity at different temperatures. Engineering and Applied Science Research, 51 (5). pp. 626-638. ISSN 2539-6161

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Abstract

Morinda citrifolia L., commonly known as ‘Noni’, holds significant potential in pharmaceutical research due to its bioactive constituents. This study aimed to optimise the ultrasound-assisted extraction process for yield and total flavonoid content (TFC) from M. citrifolia fruits at different temperatures (40 °C, 50 °C, and 60 °C). The extraction kinetics were analysed using four models: first-order kinetic, Peleg, power law, and two-site kinetic, determined through goodness-of-fit. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Results showed the peak extraction yield at 40 °C within 90 min, yielding 1.46 ± 0.01 mg/mL, while the peak TFC was at 50 °C within 100 min, yielding 3.43 ± 0.00 mg CE/g db. The two-site kinetic model best described the extraction kinetics based on goodness of fit. The IC50 value for DPPH inhibition was 1883.57 ± 0.02 µg/mL at 50 °C, indicating moderate antioxidant activity compared to ascorbic acid (95.11 ± 0.13 µg/mL). Overall, M. citrifolia fruits provide valuable insights for standardised extraction methods, potentially benefiting therapeutic applications and indirectly reducing operational costs and time for manufacturers.

Item Type:	Article
Keyword:	Morinda citrifolia, Yield, Flavonoids, Extraction kinetics, Antioxidant
Subjects:	Q Science > QK Botany > QK1-989 Botany > QK1-474.5 General Including geographical distribution R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Department:	FACULTY > Faculty of Food Science and Nutrition
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	23 Jul 2025 15:04
Last Modified:	23 Jul 2025 15:04
URI:	https://eprints.ums.edu.my/id/eprint/44618

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