RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case control study

Chong, Eric Tzyy Jiann and Lee, Chong Cin and Chua, Kek Heng and Chuah, Jitt Aun and Lee, Ping-Chin (2014) RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case control study. BMJ Open, 4 (1). pp. 1127-1132. ISSN 2044-6055

Preview	Text RsaI_but_not_DraI_polymorphism.pdf Download (50kB) | Preview
	Text RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians, a case control study.pdf Restricted to Registered users only Download (621kB)

Abstract

Objectives: Our study aimed to investigate the association of CYP2E1 C-1019T RsaI and T7678A DraI polymorphisms and factors such as age, gender and ethnicity to the risk of gastrointestinal cancer (GIC) in Malaysians. Design: Case-control study. Setting: Malaysia. Participants: 520 consented healthy blood donors with no previous GIC record and 175 patients with GIC. Measurements: C-1019T RsaI and T7678A DraI genotyping of CYP2E1 gene; direct sequencing. Results: This study reveals that the variant c2 allele and carrier with at least one c2 allele of C-1019T single nucleotide polymorphism (SNP) significantly increased the risk of GIC but no significant association was found between T7678A SNP and combined analysis of C-1019T and T7678A SNPs to risk of GIC. The Malaysian Chinese had greater risk of GIC compared with the Malays, Indians and KadazanDusun. An increased risk of GIC was observed in individuals aged >40 years and women had a 2.22-fold and 1.58-fold increased risk of stomach and colorectal cancers, respectively, when compared with men. Limitations: The future research should be conducted with a larger sample population and including the gene-gene and gene-environmental interactions. Conclusions: Our study suggests that the rare c2 allele and carrier with at least one c2 allele of CYP2E1 RsaI polymorphism significantly elevated the risk of GIC and may be used as a genetic biomarker for early screening of GIC in Malaysians. The risk age-group has been shifted to a younger age at 40s and women showed a significant greater risk of stomach and colorectal cancers than men.

Item Type:	Article
Keyword:	C-1019T RsaI , T7678A Dral SNPs , CYP2E1 polymorphisms , gastrointestinal cancer
Subjects:	R Medicine > R Medicine (General)
Depositing User:	MDM FAUZIAH MATSIN
Date Deposited:	26 Mar 2014 15:00
Last Modified:	07 Apr 2021 16:00
URI:	https://eprints.ums.edu.my/id/eprint/8527

Actions (login required)

View Item