2-Acetoxyverecynarmin C, a New briarane COX inhibitory diterpenoid from pennatula aculeate

Anu Bahl, and Sanjay M Jachak, and Kishneth Palaniveloo, and Tulasiramanan Ramachandram, and Charles Santhanaraju Vairappan, and Harish K Chopra, (2014) 2-Acetoxyverecynarmin C, a New briarane COX inhibitory diterpenoid from pennatula aculeate. Natural Product Communications, 9 (8). pp. 1139-1141. ISSN 1555-9475


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A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2-Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.

Item Type: Article
Uncontrolled Keywords: Pennatula aculeata, Briarane diterpenoid, COX-1, COX-2, 2-Acetoxyverecynarmin C.
Subjects: Q Science > Q Science (General)
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 30 Oct 2015 04:19
Last Modified: 12 Oct 2017 04:21
URI: http://eprints.ums.edu.my/id/eprint/11962

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