Assessment of anti-inflammatory effect of 5β-hydroxypalisadin B isolated from red seaweed Laurencia snackeyi in zebrafish embryo in vivo model

W.A.J.P. Wijesinghe, and Eun-A Kim, and Min-Cheol Kang, and Won, Woo Lee and Hyi-Seung Lee, and Charles Santhanaraju Vairappan, Assessment of anti-inflammatory effect of 5β-hydroxypalisadin B isolated from red seaweed Laurencia snackeyi in zebrafish embryo in vivo model.

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Abstract

5β-Hydroxypalisadin B, a halogenated secondary metabolite isolated from red seaweed Laurencia snackeyi was evaluated for its anti-inflammatory activity in lipopolysaccharide (LPS)-induced zebrafish embryo. Preliminary studies suggested the effective concentrations of the compound as 0.25, 0.5, 1μg/mL for further in vivo experiments. 5β-Hydroxypalisadin B, exhibited profound protective effect in the zebrafish embryo as confirmed by survival rate, heart beat rate, and yolk sac edema size. The compound acts as an effective agent against reactive oxygen species (ROS) formation induced by LPS and tail cut. Moreover, 5β-hydroxypalisadin B effectively inhibited the LPS-induced nitric oxide (NO) production in zebrafish embryo. All the tested protective effects of 5β-hydroxypalisadin B were comparable to the well-known anti-inflammatory agent dexamethasone. According to the results obtained, 5β-hydroxypalisadin B isolated from red seaweed L. snackeyi could be considered as an effective anti-inflammatory agent which might be further developed as a functional ingredient.

Item Type: Article
Uncontrolled Keywords: 5β-Hydroxypalisadin B, red seaweed, anti-inflammatory, Laurencia snackeyi
Subjects: S Agriculture > SH Aquaculture. Fisheries. Angling > SH393 Seagrasses
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 01 Oct 2015 02:01
Last Modified: 12 Oct 2017 04:23
URI: http://eprints.ums.edu.my/id/eprint/11968

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