Antioxidant and hepatoprotective effects of selected herbal plants from Sabah, Malaysia

Charles, Gnanaraj John Sandanaraj (2011) Antioxidant and hepatoprotective effects of selected herbal plants from Sabah, Malaysia. Universiti Malaysia Sabah. (Unpublished)

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Abstract

In this study, the hepatoprotective effects of Eleusine indica and Thysanolaena latifolia against C04-induced acute liver damage in albino rats were Investigated. Total phenolic content of E. Indica and T. latifolia and 1,1-diphenyt-2-picrylhydrazyl (OPPH) free radical scavenging were determined In-vitro. Rats were pretreated with E. indica and T. latifolia for fourteen consecutive days prior to the administration of C04 (two doses). The serum levels of alanine aminotransferase (AL 11 and aspartate aminotransferase (AST), the malondialdehyde (MDA), reduced glutathione (GSH) and some liver enzymatic activities from the post mitochondrial supernatant (PMS), and histopathological changes in rat liver sections were determined. Total phenolic content of E. indica and T. latifolia were found to be 14.9 ± 0.002 and 20.3 ± 0.007 mglg total phenolic expressed as galliC add equivalent per gram of extract. The extracts were able to reduce the stable DPPH In a dose dependent manner. The ICso value for E. Indica and T. latifolia were found to be 2350 ",g/ml and 1525 J.l9/ml. E. indica and T. latifolia Significantly prevented the increase In serum AL T and AST levels In acute liver Injury induced by CCI4 and produced a marked recovery in the histopathological hepatic Injuries. The extent of MOA formation was reduced; the GSH concentration was Increased and liver enzymatic activities In PMS were Increased in E. indica and T. latifolia treated groups compared with the C04-intoxicated group. These results Indicate that E. Indica and T. latifolia have a significant hepatoprotective effect against oxidative damage induced by ca4 In rats, which may be due to their free radical scavenging effect and their ability to increase antioxidant activity. The Inhibitory effects of a dietary extract of these plants may be useful as a hepatoprotectlve agent against chroniC chemicalinduced hepatic injury in-vivo.

Item Type:Academic Exercise
Uncontrolled Keywords:albino rat, hepatoprotective, herbal plants, liver, Eleusine indica, Thysanolaena latifolia
Subjects:T Technology > TP Chemical technology
Divisions:SCHOOL > School of Science and Technology
ID Code:12998
Deposited By:IR Admin
Deposited On:30 Jun 2016 09:53
Last Modified:30 Jun 2016 09:53

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