Antioxidative, antikinases and antimicrobial activities of macaranga tanarius

Thong, Wei Li (2008) Antioxidative, antikinases and antimicrobial activities of macaranga tanarius. Universiti Malaysia Sabah. (Unpublished)

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Abstract

The leaves extract fractions of Macaranga tanarius (M tanarius) namely hexane (HEX), dichloromethane (DCM), n-buthanol (BUT), and aqueous (AQ) extracts were analysed for its total phenolic contents, antioxidative, antikinases and antimicrobial activities. The total phenolic contents were determined based on Folin-Ciocalteu method and the results showed that BUT fraction had the highest phenolic contents among all other fractions (796 GAB in mg/g). The antioxidative activities of the extracts were then measured using the DPPH method. The results showed that BUT fraction had the highest anti oxidative activities among the accessions tested. There was a strong association between total phenolic contents and antioxidative activities (R² = 0.959), suggesting that phenolic compounds were probably responsible for the antioxdative activity of the M tanarius. The study also revealed that M tanarius exhibited only a moderate inhibition in MAPK KinaseP386 screening system and negative activity against MSGS, GSK-3β, Ras/Raf-l and PPI screening system. In antimicrobial test using disc diffusion method, BUT fraction was again the most active sample against 4 types of bacteria. Therefore as a conclusion, phenolic compounds in the BUT fraction were the major contributors to the antioxidative and antimicrobial activities of M. tanarius.

Item Type: Academic Exercise
Uncontrolled Keywords: leaves extract, Macaranga tanarius, antioxidative, antikinases, antimicrobial activities, phenolic contents, Folin-Ciocalteu method
Subjects: S Agriculture > SB Plant culture
Divisions: SCHOOL > School of Science and Technology
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 20 Jul 2016 06:15
Last Modified: 07 Nov 2017 03:19
URI: http://eprints.ums.edu.my/id/eprint/13552

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