Citrinin Derivatives from the Soil Filamentous Fungus Penicillium sp H9318

Yao, Guangmin and Sebisubi, Fred Musoke and Voo, Christopher Lok Yung and Ho , Coy Choke and Tan, Ghee Teng and Chang, Leng Chee (2011) Citrinin Derivatives from the Soil Filamentous Fungus Penicillium sp H9318. Journal of the Brazilian Chemical Society, 22 (6). 1125-U165. ISSN 0103-5053


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Investigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone (1), along with four known citrinin derivatives (2-5). Citrinin (2) exhibited significant inhibitory activity against Streptomyces 85E in the hyphae formation inhibition (HFI) assay, while compounds 1, 3-5 were not active when tested at 20 mu g/disk in the HFI assay. Citrinin (2) further demonstrated a weak inhibitory activity against MCF-7 (IC(50) 71.93 mu mol L(-1)), LNCaP (IC(50) 77.92 mu mol L(-1)), LU-1 (147.85 mu mol L(-1)) and KB (IC(50) 65.93 mu mol L(-1)) cell lines, respectively, in the cytotoxicity assay.

Item Type:Article
Uncontrolled Keywords:Streptomyces 85E, Isoquinolinone alkaloid, citrinin, Penicillium sp H9318, Kinase inhibitor
Subjects:?? QK504-(638) ??
Divisions:SCHOOL > School of Science and Technology
ID Code:1396
Deposited By:IR Admin
Deposited On:10 Aug 2011 15:04
Last Modified:17 Feb 2015 11:31

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