Cinnamomum iners as Mitogen-Activated Protein Kinase Kinase (MKK1) inhibitor

Pang, Kam Lee and Thong, Wei Li and How, Siew Eng (2009) Cinnamomum iners as Mitogen-Activated Protein Kinase Kinase (MKK1) inhibitor. International Journal of Engineering and Technology, 1 (4). pp. 310-313. ISSN 1793-8236

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Abstract

Novel inhibitors targeting signal transductions have emerged for cancer therapies. Cinnamomum species have been reported to inhibit the proliferation of various cell lines. In this study, the methanol and acetone extracts of Cinnamomum iner’s leaves demonstrated significant anti-kinase activity against MKK1 in the signal transduction pathway at quantity as low as 1 and 6 mg respectively. Both of the extracts were found to contain polyphenol and flavonoid with potent anti-oxidation activity against DPPH free radicals (IC50=0.2 and 0.3 mg/mL respectively). In conclusion, the extracts may serve as potential MKK1 inhibitors which can be developed into anti-cancer drug.

Item Type: Article
Uncontrolled Keywords: Anti-cancer drug, anti-kinases, Cinnamomum iners, MKK1, signal transduction
Subjects: T Technology > TP Chemical technology > TP368-456 Food processing and manufacture
Divisions: FACULTY > Faculty of Science and Natural Resources
Depositing User: Munira
Date Deposited: 06 Mar 2018 00:41
Last Modified: 06 Mar 2018 00:41
URI: http://eprints.ums.edu.my/id/eprint/19084

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