Hemophilia a genetic disorder: diagnosis, treatment and prognosis

Murtaza Mustafa, and Ay Moktar, and Firdaus Mohd Hayati, and Ell. Illzam, and Nornazirah Azizan, and AM Sharifa, (2016) Hemophilia a genetic disorder: diagnosis, treatment and prognosis. Journal of Dental and Medical Sciences, 15 (10). pp. 85-89. ISSN 2279-0861

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Abstract

Hemophilia a genetic disorder with patient’s inability to stop bleeding. There are two main types of hemophilia, hemophiliaA due to not enough clotting factor VIII and hemophilia B due to not enough factor IX,and acquired hemophilia A(AHA) caused by autoantibodies against clotting factor VIII(FVIII).AHA is associated with malignancy,autoimmune disorders, and pregnancy. Factor IX deficiency can cause interference of the coagulation cascade. People with more severe hemophilia usually suffer more severe and more bleeds than people with mild hemophilia. Complications of hemophilia include deep internal bleeding, joint damage, transfusion induced infection, adverse reactions to clotting factor treatment, and intracranial hemorrhage. Diagnosis of hemophilia can be confirmed by, coagulation screening test, bleeding scores and coagulation factor assay. Gold standard of treatment is rapid treatment of bleeding episodes decreases damage to the body.Prophylactic treatment although high costs, is more effective than on demand treatment. People with severe hemophilia without adequate treatment have generally shortened lifespans. Gene therapy is not currently an accepted treatment for hemophilia.

Item Type: Article
Uncontrolled Keywords: Bleeding,Diagnosis,Factor VIII&F IX, Hemophlia, Treatment
Subjects: R Medicine > RC Internal medicine
Divisions: FACULTY > Faculty of Medicine and Health Sciences
Depositing User: Munira
Date Deposited: 20 Jun 2018 00:21
Last Modified: 20 Jun 2018 00:21
URI: http://eprints.ums.edu.my/id/eprint/20308

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