Cheenpracha, Sarot and Borris, Robert P. and Tran, Tammy T. and Jap, Meng Jee and Seow, Heng Fong and Hwen, Y. Cheah and Coy , Choke Ho and Leng, Chee Chang (2011) Three new amides from streptomyces sp. H7372. Journal of the Brazilian Chemical Society, 22 (2). pp. 223-229. ISSN 0103-5053
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Official URL: http://dx.doi.org/10.1590/S0103-50532011000200006
Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(δAla-L- Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two- hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His- and inactive on SD His+ at 2.5 μg per disk, respectively. © 2011 Sociedade Brasileira de Química.
|Uncontrolled Keywords:||Amides, Cyclo(AAla-L-Val, Ras-Raf-1 interaction, Streptomyces sp., Yeast two-hybrid screen|
|Subjects:||Q Science > QP Physiology|
|Divisions:||SCHOOL > School of Science and Technology|
|Deposited By:||IR Admin|
|Deposited On:||23 Mar 2011 16:06|
|Last Modified:||08 Sep 2014 10:18|
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