Three new amides from streptomyces sp. H7372

Cheenpracha, Sarot and Borris, Robert P. and Tran, Tammy T. and Jap, Meng Jee and Seow, Heng Fong and Hwen, Y. Cheah and Coy , Choke Ho and Leng, Chee Chang (2011) Three new amides from streptomyces sp. H7372. Journal of the Brazilian Chemical Society, 22 (2). pp. 223-229. ISSN 0103-5053

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Official URL: http://dx.doi.org/10.1590/S0103-50532011000200006

Abstract

Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(δAla-L- Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two- hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His- and inactive on SD His+ at 2.5 μg per disk, respectively. © 2011 Sociedade Brasileira de Química.

Item Type:Article
Uncontrolled Keywords:Amides, Cyclo(AAla-L-Val, Ras-Raf-1 interaction, Streptomyces sp., Yeast two-hybrid screen
Subjects:Q Science > QP Physiology
Divisions:SCHOOL > School of Science and Technology
ID Code:2192
Deposited By:IR Admin
Deposited On:23 Mar 2011 16:06
Last Modified:08 Sep 2014 10:18

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