Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease

Samina Khan Yusufzai, and Mohammad Shaheen Khan, and Othman Sulaiman, and Hasnah Osman, and Dalily Nabilah Lamjin, (2018) Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease. Chemistry Central Journal, 12 (128). pp. 1-57.

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Abstract

Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Therefore, the objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017.

Item Type: Article
Uncontrolled Keywords: Coumarin, Neurodegenerative disorder, Alzheimer’s disease, Acetylcholinesterase, Butyrylcholinesterase, Monoamine oxidase
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: FACULTY > Faculty of Science and Natural Resources
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 21 Nov 2019 23:18
Last Modified: 21 Nov 2019 23:18
URI: http://eprints.ums.edu.my/id/eprint/24163

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