A new epi-neoverrucosane-type diterpenoid from the liverwort Pleurozia subinflata in Borneo

Takashi Kamada, and Mary Lyn Johanis, and Ng, Shean Yeaw and Phan, Chin Soon and Monica Suleiman, and Charles S. Vairappan, (2020) A new epi-neoverrucosane-type diterpenoid from the liverwort Pleurozia subinflata in Borneo. Natural Products and Bioprospecting, 10. pp. 51-56.

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Abstract

New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia’s liverwort Pleurozia subinfata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinfata in Borneo. Compound 3 was widespread in marine sponges however this is the frst record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited efective antifungal activity against Lagenidium thermophilum.

Item Type: Article
Uncontrolled Keywords: Epi-neoverrucosane, Diterpenoid, Pleurozia subinfata, Liverwort, Borneo
Subjects: S Agriculture > S Agriculture (General)
S Agriculture > SB Plant culture
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 02 Jun 2020 08:54
Last Modified: 02 Jun 2020 08:54
URI: http://eprints.ums.edu.my/id/eprint/25472

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