Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp.

Phan, Chin Soon and Takashi Kamada and Toshiyuki Hamada and Charles Santhanaraju Vairappan (2018) Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. Records of Natural Products, 12 (6). pp. 643-647.

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Abstract

Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.

Item Type: Article
Uncontrolled Keywords: Borneo, sponge, sesterterpenes, adult T-cell leukemia
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: SITI AZIZAH BINTI IDRIS -
Date Deposited: 10 Jun 2020 07:29
Last Modified: 10 Jun 2020 07:29
URI: http://eprints.ums.edu.my/id/eprint/25502

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