Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo

Takashi Kamada, and Min-Cheol Kang, and Phan, Chin Soon and Intan Irna Zanil, and You-Jin Jeon, and Charles Santhanaraju Vairappan, (2018) Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo. marine drugs, 16 (99). pp. 1-14.

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Abstract

Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide(1),(E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca [β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC50 values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations.

Item Type: Article
Uncontrolled Keywords: cembrane, terpenoid, soft coral, Sinularia, anti-inflammation, apoptosis structure-activity relationship
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 19 Jun 2020 00:13
Last Modified: 19 Jun 2020 00:13
URI: http://eprints.ums.edu.my/id/eprint/25522

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