Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata

Toshiyuki Hamada, and Kazushi Kobayashi, and Naomichi Arima, and Fumito Tani, and Charles Santhanaraju Vairappan, and Satoaki Onitsuka, and Hiroaki Okamura, (2020) Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata. Natural Product Research.

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Abstract

The red alga Chondria armata is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga C. armata from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, bandokorols A (1) and B (2). The structures of these compounds were determined based on spectroscopic data such as infrared (FTIR), 1H-NMR, APT, 1H–1H-COSY, HSQC, HMBC, NOESY and FAB mass spectrometry (HRFABMS). The anticancer potentials of these compounds were tested against adult T-cell leukaemia (ATL), S1T cells and their IC50 values are reported here.

Item Type: Article
Uncontrolled Keywords: Chondria armata, Rhodomelaceae, red alga, cytotoxicity, triterpenoids, adult T-cell leukemia, S1T
Subjects: Q Science > Q Science (General)
Divisions: SCHOOL > Institute for Tropical Biology and Conservation
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 21 Sep 2020 00:24
Last Modified: 21 Sep 2020 00:24
URI: http://eprints.ums.edu.my/id/eprint/25981

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