Antioxidant, antibacterial and cytotoxic activities of essential oils and ethanol extracts of selected South East Asian herbs

Lee, Tan Kai and Charles Santhanaraju Vairappan, (2011) Antioxidant, antibacterial and cytotoxic activities of essential oils and ethanol extracts of selected South East Asian herbs. Journal of Medicinal Plant Research, 5 (1). pp. 5284-5290. ISSN 1996-0875

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Abstract

Antioxidant, antibacterial and cytotoxic activities of essential oils and ethanol extracts of four South East Asian traditional herbs were investigated. Their essential oils were analyzed by Gas chromatography mass spectrometry (GC-MS) and a total of 57 types of volatile organics were identified. Artemisia argyi, Centella asiatica, Cosmos caudatus, and Polygonum hydropiper contained 30, 20, 19 and 21 types of volatiles, respectively. The major volatile hydrocarbon for A. argyi, C. asiatica and C. caudatus was a-cadinene while dodecanal was the major component for P. hydropiper. Total phenolic content of ethanol extracts analyzed by Folin-Ciocalteu method were in the range of 31.58±3.08 to 84.03±8.15 mg GAE/100 g. Free radical-scavenging activity of the four ethanol extracts were in the range of 654.43±17.22 to 5857.54±164.13 mg AA/100 g; while ferric-reducing antioxidant power were in the range of 26.58±1.10 to 50.08±0.71 mg AAE/g. Essential oils of all four species were inactive for both these assays. Ethanol extracts of these herbs were active against 60 to 80% of ten strains of human pathogenic bacteria tested, compared to 20 to 50% inhibition for essential oils. Only ethanol extracts of A. argyi and C. caudatus showed activity against P388 murine leukemia cell line, while all the essential oils were inactive.

Item Type:Article
Uncontrolled Keywords:Antimicrobial, Antioxidant, Cytotoxicity, Essential oils; Ethanol extracts, Total phenolic content, Alcohol, Alpha cadinene, Artemisia argyi extract, Centella asiatica extract, Cosmos caudatus extract, Essential oil, Hydrocarbon, Plant extract, Polygonum hydropiper extract, Terpenoid, Unclassified drug, Animal cell, Antibacterial activity, Antioxidant activity, Artemisia, Artemisia argyi, Centella asiatica, Controlled study, Cosmos (genus), Cosmos caudatus, Cytotoxicity, Drug inhibition, Leukemia cell line, Mouse, Nonhuman, Polygonum, Polygonum extract, Species differentiation, Treatment response, Artemisia argyi, Centella asiatica, Cosmos caudatus, Murinae, Persicaria hydropiper
Subjects:R Medicine > RS Pharmacy and materia medica
Divisions:SCHOOL > Institute for Tropical Biology and Conservation
ID Code:4883
Deposited By:IR Admin
Deposited On:17 Sep 2012 20:46
Last Modified:16 Feb 2015 11:32

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