Evaluation of anti-hyperglycaemic effect of Leucosyke capitellata leaf in normal and streptozotocin - induced diabetic rats

Ling, Lina (2008) Evaluation of anti-hyperglycaemic effect of Leucosyke capitellata leaf in normal and streptozotocin - induced diabetic rats. Universiti Malaysia Sabah. (Unpublished)

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Abstract

Leucosyke capitellata (Poir.) Wedd. is believed to has potential to treat diabetes and was traditionally used by Kadazandusun ethnic in Sabah. There were three objectives of this study: determination of total phenolic contents in L. capitellata leaves by Folin-Ciocalteu method, determination of antioxidant activity in L. capitellata leaves using DPPH free radical scavenging assay and to evaluate the effect of the L. capitellata leaves extract on blood glucose levels and body weight in normal and streptozotocin - induced diabetic rats. In this study, L. capitellata leaves extract showed a high value of total phenolic content which was 121.6 ± 4.0 mg/g sample. The antioxidant activity of L. capitellata leaves extract shows the highest value (78.32 ± 1.31 %) at the concentration of 100 J.lg/ml. Meanwhile, the EC₅₀ value of L. capitellata leaves extract was 16.20 ± 0.51. In animal study, there was no significant different (p > 0.05) on blood glucose level and body weight in normal rats treated with L. capitellala leaves extract. On the other hand, there was a significant reduction (p < 0.05) of blood glucose level in diabetic rats treated with L. capilellata leaves extract. Thus, it could be suggested that L. capitellata leaves extract has the ability to reduce the oxidative stress and possess antihyperglycaemic effect in diabetic rats due to its antioxidant property.

Item Type: Academic Exercise
Uncontrolled Keywords: Leucosyke capitellata (Poir.), Diabetes disease, Total phenolic, Folin-Ciocalteu, Kadazandusun ethnic, Sabah
Subjects: ?? QK710-899 ??
?? RS160-167 ??
Divisions: SCHOOL > School of Science and Technology
Depositing User: Unnamed user with email storage.bpmlib@ums.edu.my
Date Deposited: 11 Dec 2012 09:56
Last Modified: 13 Oct 2017 06:12
URI: http://eprints.ums.edu.my/id/eprint/5556

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