Antimycobcaterium activity of Allium cepa targeting isocitrate lyase, malate synthase and two-component system

Khow, Pei Ling (2008) Antimycobcaterium activity of Allium cepa targeting isocitrate lyase, malate synthase and two-component system. Universiti Malaysia Sabah. (Unpublished)

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Abstract

Tuberculosis is one of the most serious diseases that caused by Mycobacterium tuberculosis. In this study, crude, petroleum ether, n-butanol, chlorofonn and methanol aqueous extracts of A. cepa were evaluated for its anti-mycobacterium property against H8000 M smegmatis mc²155 targeting on the ICL and MS in the glyoxylate cycle and two-component system. The crude extract showed no inhibition while the petroleum ether extract showed inhibition in the glyoxylate assay targeting ICL and MS but it might not be potent enough to be further developed into an antipersistent TB drug whereas the chloroform and n-butanol extracts were cytotoxic. In the two-component system, the n-butanol extract showed inhibition but it might not be potent enough to be developed into a new anti-TB drug whereas the petroleum ether and chloroform extracts were cytotoxic. Further purification of the cytotoxic compound from A. cepa might help in the development of A. cepa into new anti-TB drug.

Item Type: Academic Exercise
Uncontrolled Keywords: tuberculosis, extraction, cytotoxic compound, A. cepa, anti-TB drug, inhibition
Subjects: T Technology > TP Chemical technology
Divisions: SCHOOL > School of Science and Technology
Depositing User: MDM SITI AZIZAH IDRIS
Date Deposited: 19 May 2014 02:09
Last Modified: 13 Oct 2017 03:30
URI: http://eprints.ums.edu.my/id/eprint/8869

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