Chemistry of bioactive metabolites in sponges collected from Sabah waters

Ho, Nina Ann Jin (2005) Chemistry of bioactive metabolites in sponges collected from Sabah waters. Universiti Malaysia Sabah. (Unpublished)


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Porifera are the most primitive multicellular animals. An estimated 10,000 species of sponges are found in both marine and freshwater distributed around the world Porifera, well known of their secondary metabolites, also show biological activities such as anti-inflammatory, antifungal, antibacterial, antitumour and cytotoxic acitivity. Hence, the functional roles of these secondary metabolites have been under study in recent decades. The seven species of marine sponges Haliclona sp., Spongia sp., Clathria sp., Gelliodes sp., Stylolella aurantium, Coelocarteria sp. and Asteropus sarassinorum collected from Sabah waters were extracted in hexane, 90% methanol and butanol crude extracts. All the extracts from seven species showed antibacterial activities against marine environmental bacteria, Clostridium sordelli and Clostridium novyi. The long chain saturated hydrocarbon compound was isolated from the hexane extract of Haliclona sp. with the extract percentage of 7.89%. This compound showed antibacterial activity against Clostridium sordelli.

Item Type: Academic Exercise
Keyword: sponges, extraction, Preparative Thin Layer Chromatography (PTLC), Column Chromatography (CC), Porifera
Subjects: Q Science > QH Natural history > QH301-705.5 Biology (General)
Department: SCHOOL > School of Science and Technology
Date Deposited: 16 Jan 2015 14:25
Last Modified: 24 Oct 2017 11:13

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