A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus

Monica Suleiman and Ng, Yeaw Ng and Charles Santhanaraju Vairappan and Takashi Kamada (2015) A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.


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A new compound, chandonanol (1), along with four known compounds, chandonanthone (2), iso-chandonanthone (3), anastreptene (4), and (6R,7S)-sesquiphellandrene (5), was isolated from the MeOH extract of Bornean liverwort Chandonanthus hirtellus. The structure of the new metabolite was established by analyses of the spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). These compounds were tested for their activity against antibiotic-resistant clinical strains. Chandonanol (1) exhibited potent bactericidal activity against Staphylococcus aureus and Escherichia coli.

Item Type: Article
Keyword: Chandonanol , Chandonanthus hirtellus , Staphylococcus aureus , Escherichia coli
Subjects: Q Science > QH Natural history > QH301-705.5 Biology (General)
Department: INSTITUTE > Institute for Tropical Biology and Conservation
Depositing User: ADMIN ADMIN
Date Deposited: 11 Feb 2016 09:30
Last Modified: 16 Oct 2017 15:33
URI: https://eprints.ums.edu.my/id/eprint/12885

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