Sarot, Cheenpracha and Zhang, Hui and Annie M. N. Mar and Adam P. Foss and Foo, Sek Hin and Lai, Ngit Shin and Jee, Jap Meng and Seow, Heng Fong and Ho, Coy Choke and Chang, Leng Chee (2009) Yeast glycogen synthase kinase-3 beta pathway inhibitors from an organic extract of streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864
|
Text
Yeast_glycogen_synthase_kinase-3_beta_pathway_inhibitors_from_an_organic_extract_of_streptomyces_sp..pdf Download (207kB) | Preview |
Abstract
Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2'-(phenylacetyl)propanimide (5), and 2-amino-N-(2'-(cyclohex-2 ''-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-alpha-rhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, (1)H and (13)C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3 beta assay.
| Item Type: | Article |
|---|---|
| Keyword: | Cycloheximide, Kinase, Ring |
| Subjects: | Q Science > QK Botany > QK1-989 Botany > QK504-(638) Cryptogams |
| Department: | SCHOOL > School of Science and Technology |
| Depositing User: | ADMIN ADMIN |
| Date Deposited: | 16 Aug 2011 15:28 |
| Last Modified: | 19 Oct 2017 10:42 |
| URI: | https://eprints.ums.edu.my/id/eprint/1365 |
Actions (login required)
 |
View Item |