Citrinin Derivatives from the Soil Filamentous Fungus Penicillium sp H9318

Yao, Guangmin and Sebisubi, Fred Musoke and Voo, Christopher Lok Yung and Ho, Coy Choke and Tan, Ghee Teng and Chang, Leng Chee (2011) Citrinin Derivatives from the Soil Filamentous Fungus Penicillium sp H9318. Journal of the Brazilian Chemical Society, 22 (6). 1125-U165. ISSN 0103-5053


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Investigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone (1), along with four known citrinin derivatives (2-5). Citrinin (2) exhibited significant inhibitory activity against Streptomyces 85E in the hyphae formation inhibition (HFI) assay, while compounds 1, 3-5 were not active when tested at 20 mu g/disk in the HFI assay. Citrinin (2) further demonstrated a weak inhibitory activity against MCF-7 (IC(50) 71.93 mu mol L(-1)), LNCaP (IC(50) 77.92 mu mol L(-1)), LU-1 (147.85 mu mol L(-1)) and KB (IC(50) 65.93 mu mol L(-1)) cell lines, respectively, in the cytotoxicity assay.

Item Type: Article
Keyword: Streptomyces 85E, Isoquinolinone alkaloid, citrinin, Penicillium sp H9318, Kinase inhibitor
Subjects: Q Science > QK Botany > QK1-989 Botany > QK504-(638) Cryptogams
Department: SCHOOL > School of Science and Technology
Depositing User: ADMIN ADMIN
Date Deposited: 10 Aug 2011 15:04
Last Modified: 19 Oct 2017 11:46

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