C-15 halogenated acetogenin with antibacterial activity against food pathogens

Charles Santhanaraju Vairappan and Tan, Kai Lee (2009) C-15 halogenated acetogenin with antibacterial activity against food pathogens. Malaysian Journal of Science, 28 (3). pp. 263-268. ISSN 1394-3065


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As part of our continuous effort in search of bioactive secondary metabolites from marine organisms, we studied a specimen of red algae, Laurencia nangii Masuda from Banggi Island, Kudat District, Sabah. One C-15 acetogenin was isolated and identified as Z-dihydrorhodophytin (1, 15%). This compound showed 100% inhibition against the tested bacteria at 30 μgdisc-1. MIC values for Salmonella enteritidis, Vibrio cholerae and Staphalococcus aereus were 1.25 μgdisc-1, 2.25 μgdisc-1 and 2.25 μgdisc-1, respectively ; while Escherichia coli, Salmonella typhii and Salmonella thphymunium were inhibited at MIC value of 7.25 μgdisc -1. This study showed that Z-dihydrorhodophytin (1) has significant antibacterial activity against the tested food pathogens and may have potential to be used as lead pharmaceutical drug candidate in combating "antibiotic resistant bacteria".

Item Type: Article
Keyword: Antibiotic resistant bacteria, C15-acetogenin, Laurencia nangii
Subjects: ?? QR75-99.5_Bacteria ??
Q Science > QK Botany > QK1-989 Botany > QK504-(638) Cryptogams
Department: INSTITUTE > Institute for Tropical Biology and Conservation
Depositing User: ADMIN ADMIN
Date Deposited: 21 Mar 2011 19:09
Last Modified: 30 Aug 2021 22:14
URI: https://eprints.ums.edu.my/id/eprint/2481

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