Phan, Chin-Soon and Yee, Chun-Sieng and Charles Santhanaraju Vairappan and Takahiro Ishii and Takashi Kamada (2019) Sinulaflexiolide P, a cembrane-type diterpenoid from the Bornean soft coral Sinularia flexibilis. Chemistry of Natural Compounds, 55. pp. 285-288.
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Abstract
A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A−K (1−11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 μM, respectively.
| Item Type: | Article |
|---|---|
| Keyword: | Sinularia flexibilis, soft coral, diterpenoid, cembrane, antifungal |
| Subjects: | S Agriculture > SH Aquaculture. Fisheries. Angling |
| Department: | INSTITUTE > Institute for Tropical Biology and Conservation |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 02 Jun 2020 16:58 |
| Last Modified: | 02 Jun 2020 16:58 |
| URI: | https://eprints.ums.edu.my/id/eprint/25477 |
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