Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri

Mohd Khalizan Sabullah and Mohd Rosni Sulaiman and Mohd Shukri Shukor and Mohd Termizi Yusof and Wan Lutfi Wan Johari and Mohd Yunus Shukor and Amir Syahir (2015) Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri. Rendiconti Lincei, 26 (2). pp. 151-158. ISSN 1720-0776

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Abstract

Acetylcholinester ase (AChE) generally known to be sensitive toward insecticides but its sensitivity toward heavy metals was least reported. Herein, a sensitive assay for heavy metals has been pursued using AChE in a rapid and economic manner. The AChE from a mudskipper, Periophthalmodon schlosseri has been found to be sensitive toward copper > mercury > chromium > and arsenic ions at the sub parts per million levels. Field trial works showed that the assay was applicable in detecting heavy metals pollution from effluents of industrial sites at near real time and verified using ICP-OES and Flow Injection Mercury System (FIMS 400). Furthermore, hierarchical cluster analyses of inhibition profiles were performed, revealing a comparable capability of the AChE compared to the gold standard of Microtox™ method.

Item Type: Article
Uncontrolled Keywords: Acetylcholinesterase , Field Trial , Heavy Metals , Hierarchical Cluster Analyses , Periophthalmodon Schlosseri
Subjects: Q Science > QD Chemistry
T Technology > TN Mining engineering. Metallurgy
Divisions: FACULTY > Faculty of Science and Natural Resources
Depositing User: SAFRUDIN BIN DARUN -
Date Deposited: 26 Jun 2021 09:43
Last Modified: 26 Jun 2021 09:43
URI: https://eprints.ums.edu.my/id/eprint/27449

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