Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo

Hoh, Boon Peng and Xiaoxi Zhang and Lian Deng and Kai Yuan and Yew, Chee Wei and Saw, Woei Yuh and Mohammad Zahirul Hoque and Farhang Aghakhanian and Maude E. Phipps and Vijay Kumar Subbiah and Xu, Shu hua (2020) Shared signature of recent positive selection on the TSBP1-BTNL2-HLA-DRA genes in five native populations from North Borneo. Genome biology and evolution, 12 (12). pp. 2245-2257. ISSN 1759-6653

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Abstract

North Borneo (NB) is home to more than 40 native populations. These natives are believed to have undergone local adaptation in response to environmental challenges such as the mosquito-abundant tropical rainforest. We attempted to trace the footprints of natural selection from the genomic data of NB native populations using a panel of 2.2 million genome-wide single nucleotide polymorphisms. As a result, an 13-kb haplotype in the Major Histocompatibility Complex Class II region encompassing candidate genes TSBP1–BTNL2–HLA-DRA was identified to be undergoing natural selection. This putative signature of positive selection is shared among the five NB population sandis estimated to have arisen5.5thousand years(220generations) ago, which coincides with the period of Austronesian expansion. Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. The findings of this study imply that despite high levels of genetic differentiation, the NB populations might have experienced similar local genetic adaptation resulting from stresses of the shared environment.

Item Type: Article
Keyword: Natural Selection , North Borneo , Malaria , BTNL2 , TSBP1 , HLA-DRA
Subjects: R Medicine > R Medicine (General)
Department: FACULTY > Faculty of Medicine and Health Sciences
Depositing User: NORAINI LABUK -
Date Deposited: 01 Jul 2021 22:12
Last Modified: 01 Jul 2021 22:18
URI: https://eprints.ums.edu.my/id/eprint/27521

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