Nornazirah Azizan and Firdaus Hayati and Nur Maya Sabrina Tizen and Wirda Indah Farouk and Noraidah Masir (2018) Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma. Investigative and Clinical Urology, 59. pp. 232-237. ISSN 2466-0493 (P-ISSN) , 2466-054X (E-ISSN)
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Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma ABSTRACT.pdf Download (64kB) |
Abstract
Purpose: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. Materials and Methods: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and Ki67 was analyzed according to Gleason score categorized into prognostic groups of 1 to 5. Double-immunofluorescent staining of ER-beta and Ki67 was performed in a total of 20 cases to study the co-expression and the relationship between these markers within the same tumor. Results: A total of 53 of 101 cases (52.5%) were positive for ER-beta expression. There was a positive correlation whereby a high percentage of ER-beta expression was seen in the higher prognostic groups (groups 4 and 5; p=0.007). High Ki67 expression was observed in the higher prognostic group, whereas low Ki67 or negative expression was found in the lower prognostic group (p<0.001). The majority of cases evaluated with double-immunofluorescent staining (14/20) showed co-expression of ER-beta and Ki67 at the individual cell level. Conclusions: ER-beta and Ki67 are independent tumor markers in high prognostic groups. Hence, co-expression of ER-beta and Ki67 indicates a more aggressive tumor with a poorer prognosis.
| Item Type: | Article |
|---|---|
| Keyword: | Estrogen receptor beta , Ki-67 antigen , Neoplasm grading , Prostate neoplasms |
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC870-923 Diseases of the genitourinary system. Urology |
| Department: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | SAFRUDIN BIN DARUN - |
| Date Deposited: | 22 Oct 2021 11:29 |
| Last Modified: | 22 Oct 2021 11:29 |
| URI: | https://eprints.ums.edu.my/id/eprint/30583 |
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