Cranial diabetes insipidus in neuropsychiatrie systemic lupus erythematosus, a rare but treatable association: A case report

Alvin Oliver Payus and Malehah Mohd Noh and Constance Liew Sat Lin and Justin Leow Wen Hsiang and Ani Darwina Abdul Halim (2020) Cranial diabetes insipidus in neuropsychiatrie systemic lupus erythematosus, a rare but treatable association: A case report. Gazi Medical Journal, 31. pp. 190-193. ISSN 2147-2092

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Abstract

Systemic lupus erythematosus has been rarely reported to be associated with cranial diabetes insipidus. It is a condition clinically manifest as severe polyuria and reactive polydipsia that may lead to electrolyte imbalance or acute kidney injury as a result of arginine vasopressin insufficiency. Here, we report a patient with systemic lupus erythematosus and lupus nephritis previously under control with medication presented with neuropsychiatric symptoms which responded to pulsed methylprednisolone, developed severe polyuria, polydipsia and hypernatremia which persisted after pulsed therapy. Serum and urine osmolarity were suggestive of diabetes insipidus and the polyuria resolved dramatically after trial of oral desmopressin which in keeping with the diagnosis of central cause. The objective of this case report is to share the uncommon occurrence of diabetes insipidus in neuropsychiatric systemic lupus erythematosus.

Item Type:	Article
Keyword:	Cranial diabetes insipidus , Arginine vasopressin , Systemic lupus erythematosus
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC648-665 Diseases of the endocrine glands. Clinical endocrinology R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC924-924.5 Diseases of the connective tissues
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	23 Nov 2021 07:53
Last Modified:	23 Nov 2021 07:53
URI:	https://eprints.ums.edu.my/id/eprint/31062

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