Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells

Perng Yang Puah and Pak, Yan Moh and Coswald Stephen Sipaut @ Mohd Nasri and Ping, Chin Lee and Siew, Eng How (2021) Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells. Polymers, 13 (3290). pp. 1-13. ISSN 2073-4360

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URL: https://www.mdpi.com/2073-4360/13/19/3290/htm

Abstract

Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomaterial for culturing human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). The characterization of the peptide/m-GO films was performed, and the biocompatibility of the WJ-MSCs on the peptide/m-GO films was investigated. The results demonstrated that the peptide conjugate on the m-GO film did not hamper the normal growth of WJ-MSCs but supported the growth of WJ-MSCs after the 6-day culture period. In addition, the osteogenic differentiation of WJMSCs on the peptide/m-GO films was enhanced as compared with the parent m-GO film. Therefore, such peptide-conjugated m-GO films could provide a highly biocompatible and multifunctional 2D material to tailor the potential application of WJ-MSCs in bone tissue regeneration.

Item Type:	Article
Keyword:	Multilayer graphene oxide , Peptide , Wharton’s jelly mesenchymal stem cells , Osteogenic differentiation
Subjects:	Q Science > Q Science (General) > Q1-390 Science (General) > Q1-295 General Q Science > QD Chemistry > QD1-999 Chemistry
Department:	FACULTY > Faculty of Science and Natural Resources
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	22 Dec 2021 17:56
Last Modified:	22 Dec 2021 17:56
URI:	https://eprints.ums.edu.my/id/eprint/31529

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