Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review

Tay, Kai Xin and Mohd Firdaus Mohd Hayati and Fairrul Masnah @ Kadir and Win, Win Than and Abdel Mohsen Mohamed Ahmed Abdel Hafez (2022) Pemphigoid Gestationis and adverse pregnancy outcomes: A literature review. Journal of Gynecology Obstetrics and Human Reproduction, 51 (102370). pp. 1-8. ISSN 2468-7847

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Pemphigoid gestationis (PG), also known as gestational pemphigoid, as it is specifically associated with a pregnancy event, is among the rare pregnancy-related dermatoses, characterised by the formation of autoantibodies against Bullous Pemphigoid antigens 180 and 230 (BP180 and BP230), causing significant damage to the basement membrane of the skin, resulting in marked pruritus and blisters on the abdomen and extremities. Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies and histopathology of a skin biopsy. Treatment, just as for other autoimmune dermatoses, is achieved by corticosteroids with the risk of relapses in subsequent pregnancies. Fetal growth restriction and pre-maturity are potential fetal complications associated with the disease, hence the recommended combined antenatal care by a dermatologist as well as an obstetrician, however, this disease is unlikely to be a source of significant maternal morbidity or mortality.

Item Type: Article
Keyword: Pregnancy dermatoses , Adverse outcomes , Corticosteroids , Fetal growth restriction , Fetal demise
Subjects: R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics > RG500-991 Obstetrics
Department: FACULTY > Faculty of Medicine and Health Sciences
Depositing User: SAFRUDIN BIN DARUN -
Date Deposited: 21 Jul 2022 12:06
Last Modified: 21 Jul 2022 12:06

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