Comprehensive approaches for the detection of Burkholderia pseudomallei and diagnosis of melioidosis in human and environmental samples

Siti Nur Hazwani Oslan and Abdul Hafidz Yusoff and Mazlina Mazlan and Si Jie Lim and Jing Jing Khoo and Siti Nurbaya Oslan and Aziah Ismail (2022) Comprehensive approaches for the detection of Burkholderia pseudomallei and diagnosis of melioidosis in human and environmental samples. Microbial Pathogenesis, 169. ISSN 0880-4010 (P-ISSN) , 1096-1208 (E-ISSN)

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Abstract

Melioidosis is endemic in Southeast Asia and northern Australia. The causative agent of melioidosis is a Gram-negative bacterium, Burkholderia pseudomallei. Its invasion can be fatal if melioidosis is not treated promptly. It is intrinsically resistant to a variety of antibiotics. In this paper, we present a comprehensive overview of the current trends on melioidosis cases, treatments, B. pseudomallei virulence factors, and molecular techniques to detect the bacterium from different samples. The clinical and microbial diagnosis methods of identification and detection of B. pseudomallei are commonly used for the rapid diagnosis and typing of strains, such as polymerase chain reaction or multi-locus sequence typing. The genotyping strategies and techniques have been constantly evolving to identify genomic loci linked to or associated with this human disease. More research strategies for detecting and controlling melioidosis should be encouraged and conducted to understand the current situation. In conclusion, we review existing diagnostic methodologies for melioidosis detection and provide insights on prospective diagnostic methods for the bacterium.

Item Type:	Article
Keyword:	Burkholderia pseudomallei , Diagnosis , Melioidosis , Molecular tools , Vaccine , Virulence mechanism
Subjects:	Q Science > QR Microbiology > QR1-502 Microbiology > QR75-99.5 Bacteria
Department:	SCHOOL > School of Food Science and Nutrition
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	25 Jul 2022 09:02
Last Modified:	08 Sep 2022 08:39
URI:	https://eprints.ums.edu.my/id/eprint/33509

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