Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms

Balu Alagar Venmathi Maran and Mohammad Iqbal and Prakash Gangadaran and Ahn, Byeong-Cheol and Pasupuleti Visweswara Rao and Muhammad Dawood Shah (2022) Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms. Molecules, 27 (1533). pp. 1-19. ISSN 1420-3049

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URL: https://www.mdpi.com/1420-3049/27/5/1533

Abstract

Hepatotoxicity is a major global public health concern. Despite advances in modern medicine, the demerits of chemically prepared drugs outweigh their merits. In addition, the treatment of liver diseases based on modern medical principles has been found to produce several undesired side effects. Therefore, the exploration of medicinal plants has gained worldwide attention for treating various diseases, including liver diseases, owing to their potential efficacy and cost effectiveness. Several plants, including Andrographis paniculata, Bauhinia purpurea, Commelina nudiflora, Dillenia suffruticosa, Elaeis guineensis, Lygodium microphyllum, and Nephrolepis biserrata, have been reported with hepatoprotection. Moreover, these plants have been shown to play a vital role in ameliorating cellular damage because they contain several phytochemicals, including alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones. The following antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective compounds have been found in these plants: andrographolide, rosmarinic acid, phenol, eugenol, 9,12-octadecadienoic, n-hexadecanoic acid, dihydroxy dimethoxy flavone, sitosterol, demethoxycurcumin, quercetin, linoleic acid, stigmasterol, kojic acid, indole-2-one, α-terpinol, linalool, kaempferol, catechin, ellagic acid, and oleanolic acid. This paper aimed to provide an in-depth review of in vivo studies on Malaysian medicinal plants possessing hepatoprotective properties, phytochemical ingredients, and antioxidant mechanisms, with an emphasis on the species proven particularly useful for treating hepatic disorders.

Item Type:	Article
Keyword:	Medicinal plants , Oxidative stress , Phytochemicals , Hepatoprotective , Carbon tetrachloride
Subjects:	Q Science > QK Botany > QK1-989 Botany
Department:	INSTITUTE > Borneo Marine Research Institute
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	03 Aug 2022 08:18
Last Modified:	03 Aug 2022 08:18
URI:	https://eprints.ums.edu.my/id/eprint/33653

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