Xin, Bernadette Jie Tune and Maw, Shin Sim and Chit, Laa Poh and Rhanye Mac Guad and Choy, Ker Woon and Iswar Hazarika and Anju Das and Subash C. B. Gopinath and Mariappan Rajan and Mahendran Sekar and Vetriselvan Subramaniyan and Neeraj Kumar Fuloria and Shivkanya Fuloria and Kalaivani Batumalaie and Yuan, Seng Wu (2022) Matrix metalloproteinases in chemoresistance: regulatory roles, molecular interactions, and potential inhibitors. Journal of Oncology, 2022. pp. 1-25. ISSN 1687-8450 (P-ISSN) , 1687-8469 (E-ISSN)
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Matrix metalloproteinases in chemoresistance_ regulatory roles, molecular interactions, and potential inhibitors _ABSTRACT.pdf Download (60kB) |
Abstract
Cancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to the occurrence of chemoresistance. Although chemoresistance can emerge through a multitude of mechanisms, chemoresistance and metastasis share a similar pathway, which is an epithelial-to-mesenchymal transition (EMT). Matrix metalloproteinases (MMPs), a class of zinc and calcium-chelated enzymes, are found to be key players in driving cancer migration and metastasis through EMT induction. The aim of this review is to discuss the regulatory roles and associated molecular mechanisms of specific MMPs in regulating chemoresistance, particularly EMT initiation and resistance to apoptosis. A brief presentation on their potential diagnostic and prognostic values was also deciphered. It also aimed to describe existing MMP inhibitors and the potential of utilizing other strategies to inhibit MMPs to reduce chemoresistance, such as upstream inhibition of MMP expressions and MMP-responsive nanomaterials to deliver drugs as well as epigenetic regulations. Hence, manipulation of MMP expression can be a powerful tool to aid in treating patients with chemo-resistant cancers. However, much still needs to be done to bring the solution from bench to bedside.
| Item Type: | Article |
|---|---|
| Keyword: | Matrix metalloproteinases , Chemoresistance , Cancer |
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| Department: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | SAFRUDIN BIN DARUN - |
| Date Deposited: | 15 Aug 2022 09:40 |
| Last Modified: | 15 Aug 2022 09:40 |
| URI: | https://eprints.ums.edu.my/id/eprint/33751 |
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