Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

Gael Davidson and Tock, Hing Chua and Angus Cook and Peter Speldewinde and Philip Weinstein (2019) Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework. Malaria Journal, 18. pp. 1-13. ISSN 1475-2875

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URL: https://link.springer.com/article/10.1186/s12936-0...

Abstract

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales.

Item Type:	Article
Keyword:	Malaria , Zoonotic , Plasmodium knowlesi , Anthropogenic land use change
Subjects:	Q Science > QL Zoology > QL1-991 Zoology > QL360-599.82 Invertebrates
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	29 Aug 2022 09:58
Last Modified:	29 Aug 2022 09:58
URI:	https://eprints.ums.edu.my/id/eprint/34001

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