Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers

Farhang Aghakhanian and Hoh, Boon‑Peng and Yew, Chee Wei and Vijay Kumar Subbiah and Yali Xue and ChrisTyler‑Smith and Qasim Ayub and Maude E. Phipps (2022) Sequence analyses of Malaysian Indigenous communities reveal historical admixture between Hoabinhian hunter-gatherers and Neolithic farmers. Scientific reports, 12 (13743). pp. 1-11. ISSN 2045-2322

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URL: https://www.nature.com/articles/s41598-022-17884-8

Abstract

Southeast Asia comprises 11 countries that span mainland Asia across to numerous islands that stretch from the Andaman Sea to the South China Sea and Indian Ocean. This region harbors an impressive diversity of history, culture, religion and biology. Indigenous people of Malaysia display substantial phenotypic, linguistic, and anthropological diversity. Despite this remarkable diversity which has been documented for centuries, the genetic history and structure of indigenous Malaysians remain under-studied. To have a better understanding about the genetic history of these people, especially Malaysian Negritos, we sequenced whole genomes of 15 individuals belonging to five indigenous groups from Peninsular Malaysia and one from North Borneo to high coverage (30X). Our results demonstrate that indigenous populations of Malaysia are genetically close to East Asian populations. We show that present-day Malaysian Negritos can be modeled as an admixture of ancient Hoabinhian hunter-gatherers and Neolithic farmers. We observe gene flow from South Asian populations into the Malaysian indigenous groups, but not into Dusun of North Borneo. Our study proposes that Malaysian indigenous people originated from at least three distinct ancestral populations related to the Hoabinhian hunter-gatherers, Neolithic farmers and Austronesian speakers.

Item Type:	Article
Keyword:	Evolution , Genetics , Hoabinhian
Subjects:	D World History and History Of Europe, Asia, Africa, Australia, New Zealand, Etc. > DS Asia > DS1-937 History of Asia > DS520-560.72 Southeast Asia > DS591-599 Malaysia. Malay Peninsula. Straits Settlements Q Science > QH Natural history > QH301-705.5 Biology (General) > QH426-470 Genetics
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	29 Sep 2022 11:41
Last Modified:	29 Sep 2022 11:41
URI:	https://eprints.ums.edu.my/id/eprint/34337

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