Rabies in Southeast Asia a systematic review of its incidence, risk factors and mortality

Miaw Yn Jane Ling and Ahmad Farid Nazmi Abdul Halim and Dzulfitree Ahmad and Nurfatehar Ramly and Mohd Rohaizat Hassan and Syed Sharizman Syed Abdul Rahim and Mohammad Saffree Jeffree and Azizan Omar and Aizuddin Hidrus (2023) Rabies in Southeast Asia a systematic review of its incidence, risk factors and mortality. BMJ Open, 13. pp. 1-9.

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Objective Rabies is a neglected zoonotic disease that can infect all mammals, including humans. We aimed to summarise the current knowledge of the incidence, risk factors and mortality of rabies in Southeast Asia. Design Systematic review based on the Preferred Reporting Items for Systematic Reviews and MetaAnalyses 2020. Data sources Scopus, Web of Science and PubMed were searched from 1 January 2012 to 21 February 2023. Eligibility criteria Original English language articles published between 2012 and 2023 were included. Data extraction and synthesis Nine independent reviewers extracted data and assessed the risk of bias. The quality appraisal of included articles was carried out using the Mixed Methods Appraisal Tool. Results A total of eight articles were included in this analysis. In Vietnam, the incidence of rabies ranged from 1.7 to 117.2 per 100 000 population. The cumulative incidence in Sarawak was estimated at 1.7 per 100 000 population. In Indonesia, 104 human rabies cases were reported from 2008 to 2010, while in Thailand, a total of 46 rabies cases were reported in Thailand from 2010 to 2015. In the Philippines, the incidence of rabies ranged from 0.1 to 0.3 per 100 000 population. An increased risk of rabies virus infection was associated with a high population density, illiteracy, seasonal patterns and dog butchers. The case fatality rate was 100%. Conclusion This study included research from Southeast Asia, which may not represent rabies infection in other regions or continents. In addition, the role of publication bias should be acknowledged as grey literature was not included. The occurrence of rabies in Southeast Asia is due to the high number of unvaccinated stray and pet dogs, working hazards (dog butchers in Vietnam), the unavailability of the rabies vaccine in rural regions and misinformation about the significance of seeking treatment after dog bites.

Item Type: Article
Keyword: Rabies , genus Lyssavirus , canine rabies
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC109-216 Infectious and parasitic diseases
R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Department: FACULTY > Faculty of Medicine and Health Sciences
Date Deposited: 06 Sep 2023 15:36
Last Modified: 06 Sep 2023 15:36
URI: https://eprints.ums.edu.my/id/eprint/36736

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