Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model

Saheed Olanrewaju Saka and Yusuf Yahaya Salisu and Hauwa’u Muhammad Sahabi and Kamaldeen Olalekan Sanusi and Kasimu Ghandi Ibrahim and Murtala Bello Abubakar and Suleiman Ahmed Isa and Muhammad Gidado Liman and Sha’aya’u Shehu and Ibrahim Malami and Kim Wei Chan and Nur Hanisah Azmi and Mustapha Umar Imam (2023) Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model. Molecules, 28. pp. 1-23.

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Consumption of white rice (WR) has been shown to predispose individuals to metabolic disorders. However, brown rice (BR), which is relatively richer in bioactive compounds, possesses anti-glycaemic and antioxidant effects. In this study, fifteen cultivars of paddy rice that are predominantly consumed in North West Nigeria were analysed for their nutritional composition, bioactive contents and effects on metabolic outcomes in a fruit fly model. Gene expression analyses were conducted on the whole fly, targeting dPEPCK, dIRS, and dACC. The protein, carbohydrate, and fibre contents and bioactives of all BR cultivars were significantly different (p < 0.05) from the WR cultivars. Moreover, it was demonstrated that the glucose and trehalose levels were significantly higher (p < 0.05), while glycogen was significantly lower (p < 0.05) in the WR groups compared to the BR groups. Similarly, the expression of dACC and dPEPCK was upregulated, while that of dIRS was downregulated in the WR groups compared to the BR groups. Sex differences (p < 0.05) were observed in the WR groups in relation to the nutrigenomic effects. Our findings confirm metabolic perturbations in fruit flies following consumption of WR via distortion of insulin signalling and activation of glycogenolysis and gluconeogenesis. BR prevented these metabolic changes possibly due to its richer nutritional composition

Item Type: Article
Keyword: brown rice; white rice; metabolic syndrome; insulin resistance; dPEPCK; dIRS; dACC; oxidative stress; obesity; fruit fly
Subjects: Q Science > QP Physiology > QP1-(981) Physiology > QP501-801 Animal biochemistry
S Agriculture > SB Plant culture > SB1-1110 Plant culture > SB183-317 Field crops Including cereals, forage crops, grasses, legumes, root crops, sugar plants, textile plants, alkaloidal plants, medicinal plants
Department: FACULTY > Faculty of Food Science and Nutrition
Date Deposited: 13 Oct 2023 15:28
Last Modified: 13 Oct 2023 15:28

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