Human mesenchymal stromal cells derived from perinatal tissues: Sources, characteristics and isolation methods

Peik Lin Teoh and Haselamirrah Mohd Akhir and Warda Abdul Ajak and Vun Vun Hiew (2023) Human mesenchymal stromal cells derived from perinatal tissues: Sources, characteristics and isolation methods. The Malaysian Journal of Medical Sciences, 30 (2). pp. 1-14. ISSN 1394-195X

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Abstract

Mesenchymal stromal/stem cells (MSCs) derived from perinatal tissues have become indispensable sources for clinical applications due to their superior properties, ease of accessibility and minimal ethical concerns. MSCs isolated from different placenta (PL) and umbilical cord (UC) compartments exhibit great potential for stem cell-based therapies. However, their biological activities could vary due to tissue origins and differences in differentiation potentials. This review provides an overview of MSCs derived from various compartments of perinatal tissues, their characteristics and current isolation methods. Factors affecting the yield and purity of MSCs are also discussed as they are important to ensure consistent and unlimited supply for regenerative medicine and tissue engineering.

Item Type:	Article
Keyword:	perinatal tissues, mesenchymal stromal cells, surface markers, explant culture, enzymatic method
Subjects:	Q Science > QH Natural history > QH301-705.5 Biology (General) Q Science > QH Natural history > QH301-705.5 Biology (General) > QH573-671 Cytology
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	29 Feb 2024 10:30
Last Modified:	29 Feb 2024 10:30
URI:	https://eprints.ums.edu.my/id/eprint/38407

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