Siti Khadzirah Daud (2015) The relationships between plasma glucose in oral glucose tolerance test abd HbA in Queen Elizabeth Hospital Kota Kinabalu. Masters thesis, Universiti Malaysia Sabah.
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Abstract
The blood glucose level measurement is important in the diagnosis of Diabetes mellitus. As recommended by the World Health Organisation (WHO) in 1985, fasting plasma glucose (FPG) level of ≥ 7.8 mmol/L (140 mg/dL) and/or 2-hour post-glucose loading (or random plasma glucose) level of ≥ 11.1 mmol/L (200mg/dL) in Oral Gluose Tolerance Test (OGTT) are used as diagnostic criteria. Both tests are commonly used to diagnose those at risk of Type 2 Diabetes mellitus. However, recently, WHO has recommended that Hemoglobin A1c (HbA1c) with cutoff point of ≥ 6.5% can be used as a diagnostic test for Diabetes mellitus. Hence, this study was undertaken to determine whether the recommendation applies to the patient population in Queen Elizabeth Hospital Kota Kinabalu. The fasting plasma glucose and 2-hour post-glucose loading test were performed using Roche Chemistry Analyzer Modular P800 while for the HbA1c test was estimated using the PDQ Primus Plus HbA1c analyzer at the Department of Pathology, Queen Elizabeth Hospital. The data were analyzed and interpreted using the Statistical Package for The Social Sciences (SPSS) Version 18.0. There was a strong correlation between FPG test and HbA1c test. Similarly, there was a strong correlation between 2-hour post-glucose loading test and HbA1c . In conclusion, there is a strong correlation between FPG, 2-hour post-glucose loading in Oral Glucose Tolerance Test (OGTT) and HbA1c. Hence, HbA1c can be used as the diagnostic criteria with the cut-off point of 6.7% in Queen Elizabeth Hospital, Kota Kinabalu.
| Item Type: | Thesis (Masters) |
|---|---|
| Keyword: | Blood glucose level, Diabetes mellitus, Fasting plasma glucose, Oral Glucose Tolerance Test, Hemoglobin A1c, Diagnostic criteria |
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC648-665 Diseases of the endocrine glands. Clinical endocrinology |
| Department: | SCHOOL > School of Medicine |
| Depositing User: | DG MASNIAH AHMAD - |
| Date Deposited: | 11 Apr 2025 11:17 |
| Last Modified: | 11 Apr 2025 11:17 |
| URI: | https://eprints.ums.edu.my/id/eprint/43462 |
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