Phytochemical and biological studies on Fissistigma Manubriatum

Amutha Manian (2007) Phytochemical and biological studies on Fissistigma Manubriatum. Universiti Malaysia Sabah. (Unpublished)


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The plant Fissistigma manubriatum (Annonaceae) or known more commonly as Gagon has long been a source of traditional remedy curing rheumatism and fever. In this study, Fissistigma manubriatum root bark was screened for phytochemical, antioxidant and antimicrobial activities. Four types of extracts, i.e. aqueous extract 2.705g (0.54 %), hexane extract 0.637g (0.13%), dichloromethane extract 0.578g (0.12%) and butanol extract 2.810 g (0.56 %) were obtained by extraction of Fissistigma manubriatum root using solvent-solvent extraction method. Phytochemical screenings indicated that secondary metabolites such as alkaloids, saponins, tannins and flavonoids were found in dichloromethane, butanol and aqueous extracts. Antioxidation test using Ferric Thiocyanate method (FTC) indicated that butanol, aqueous and dichloromethane extracts of the sample demonstrated moderate antioxidative property compared to butylated hydroxytoulene (BHT, a synthetic antioxidant). The relative absorbance values of all these three extracts almost similar to each other indicating that they possessed a similar efficiency in inhibitory activity against linoleic acid peroxidation. An antimicrobial test using the disc diffusion method indicated that the butanol and aqueous extracts of the sample were partially active against Bacillus cereus (B 43/04B) and Staphylococcus aureus (S 277), but ineffective against Escherichia coli (E 911026) and Pseudomonas aeruginosa (ATCC 10145). In conclusion, Fissistigma manubriatum extracts showed the presence of certain classes of phytoconstituents and acted as moderate antioxidants with weaker antioxidation activity than butylated hydroxytoulene (BHT).

Item Type: Academic Exercise
Keyword: Fissistigma manubriatum, Annonaceae, Traditional medicine, Phytochemical
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry > QD241-441 Organic chemistry
Department: SCHOOL > School of Science and Technology
Depositing User: ADMIN ADMIN
Date Deposited: 09 Dec 2011 14:20
Last Modified: 12 Oct 2017 13:28

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