Anu Bahl and Sanjay M Jachak and Kishneth Palaniveloo and Tulasiramanan Ramachandram and Charles Santhanaraju Vairappan and Harish K Chopra (2014) 2-Acetoxyverecynarmin C, a New briarane COX inhibitory diterpenoid from pennatula aculeate. Natural Product Communications, 9 (8). pp. 1139-1141. ISSN 1555-9475
|
Text
2-Acetoxyverecynarmin_C,_a_New_Briarane_COX_Inhibitory_Diterpenoid_from_Pennatula_aculeat.pdf Download (128kB) | Preview |
Abstract
A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2-Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.
| Item Type: | Article |
|---|---|
| Keyword: | Pennatula aculeata, Briarane diterpenoid, COX-1, COX-2, 2-Acetoxyverecynarmin C. |
| Subjects: | Q Science > Q Science (General) |
| Department: | INSTITUTE > Institute for Tropical Biology and Conservation |
| Depositing User: | ADMIN ADMIN |
| Date Deposited: | 30 Oct 2015 12:19 |
| Last Modified: | 12 Oct 2017 12:21 |
| URI: | https://eprints.ums.edu.my/id/eprint/11962 |
Actions (login required)
 |
View Item |