2-Acetoxyverecynarmin C, a New briarane COX inhibitory diterpenoid from pennatula aculeate

Anu Bahl and Sanjay M Jachak and Kishneth Palaniveloo and Tulasiramanan Ramachandram and Charles Santhanaraju Vairappan and Harish K Chopra (2014) 2-Acetoxyverecynarmin C, a New briarane COX inhibitory diterpenoid from pennatula aculeate. Natural Product Communications, 9 (8). pp. 1139-1141. ISSN 1555-9475

[img]
Preview
Text
2-Acetoxyverecynarmin_C,_a_New_Briarane_COX_Inhibitory_Diterpenoid_from_Pennatula_aculeat.pdf

Download (128kB) | Preview

Abstract

A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2-Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.

Item Type: Article
Keyword: Pennatula aculeata, Briarane diterpenoid, COX-1, COX-2, 2-Acetoxyverecynarmin C.
Subjects: Q Science > Q Science (General)
Department: INSTITUTE > Institute for Tropical Biology and Conservation
Depositing User: ADMIN ADMIN
Date Deposited: 30 Oct 2015 12:19
Last Modified: 12 Oct 2017 12:21
URI: https://eprints.ums.edu.my/id/eprint/11962

Actions (login required)

View Item View Item