Abtholuddin M. Faris and Kambol Roziah (2008) Genome structure and characterisation of an endogenous retrovirus from the zebrafish genome project database. In: 2nd International Conference on Bioinformatics Research and Development, 07-09 July 2008, Vienna, Austria.
Full text not available from this repository.Abstract
A 9.5Kb nucleotide sequence of an endogenous retrovirus was obtained during an attempt to screen a reverse transcriptase-like element in the zebrafish genome project database. The element termed here as ZFERV-2 has the typical genomic organization of a retrovirus in which the LTR flanks the viral genes in this way: LTR-gag-pol-env-LTR. ZFERV-2, resembles a zebrafish endogenous retrovirus, ZFERV discovered previously by Shen and Steiner (2004) and has all the major conserved motifs of the viral genes. In addition, ZFERV-2 has several characteristics possessed by a retrovirus. Firstly, ZFERV-2 shows a replication defective retrovirus because of huge deletion at the protease gene proximal to gag gene is observed. Secondly, an intact genome structure of ZFERV-2 together with 99% sequence similarity on both ends of the LTRs indicate a recent integration into the zebrafish genome. Thirdly, a long leader sequence at 1.5Kb upstream of the viral genes and a large genome size are characteristics shared by retroviruses isolated from lower vertebrates.
| Item Type: | Conference or Workshop Item (UNSPECIFIED) |
|---|---|
| Keyword: | Endogenous retrovirus, Genome, Reverse transcriptase, Piscine |
| Subjects: | Q Science > QH Natural history > QH301-705.5 Biology (General) > QH426-470 Genetics |
| Department: | SCHOOL > School of Science and Technology |
| Depositing User: | ADMIN ADMIN |
| Date Deposited: | 04 Sep 2018 08:59 |
| Last Modified: | 04 Sep 2018 08:59 |
| URI: | https://eprints.ums.edu.my/id/eprint/1275 |
Actions (login required)
 |
View Item |