Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

Caillaud, Amandine and de la Iglesia, Pablo and CampÃ s, MÃ²nica and Elandaloussi, Laurence M and FernÃ¡ndez, M and Normawaty Mohamad Noor and Andree, Karl B. and DiogÃ¨ne, Jorge (2010) Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia. Toxicon, 55 (2-3). pp. 633-637. ISSN 0041-0101

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URL: http://dx.doi.org/10.1016/j.toxicon.2009.07.016

Abstract

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.

Item Type:	Article
Keyword:	Prorocentrum rhathymum; Protein phosphatase inhibition assay; Neuroblastoma cell-based assay; LC-MS/MS; Okadaic acid
Subjects:	Q Science > QK Botany
Department:	INSTITUTE > Borneo Marine Research Institute
Depositing User:	ADMIN ADMIN
Date Deposited:	24 Jan 2011 17:14
Last Modified:	30 Aug 2021 21:42
URI:	https://eprints.ums.edu.my/id/eprint/1347

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