Patricia @ Patricia Clementina Matanjun and Suhaila Mohamed and Kharidah Muhammad and Noordin Mohamed Mustapha (2010) Comparison of cardiovascular protective effects of tropical seaweeds, kappaphycus alvarezii, caulerpa lentillifera, and sargassum polycystum, on high-cholesterol/high-fat diet in rats. Journal of Medicinal Food, 13 (4). pp. 792-800. ISSN 1096-620X
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Abstract
This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260-300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (-11.4% to-18.5%), LDL-C (-22% to-49.3%), and TG (-33.7% to-36.1%) levels and significantly increased HDL-C levels (16.3-55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats. © Mary Ann Liebert, Inc.
| Item Type: | Article |
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| Keyword: | Antioxidant, Body weight, Cholesterol, Rats, Seaweeds |
| Subjects: | ?? RA0421 ?? |
| Department: | SCHOOL > School of Food Science and Nutrition |
| Depositing User: | ADMIN ADMIN |
| Date Deposited: | 03 Mar 2011 12:11 |
| Last Modified: | 20 Oct 2017 14:46 |
| URI: | https://eprints.ums.edu.my/id/eprint/1986 |
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