Yeast glycogen synthase kinase-3β pathway inhibitors from an organic extract of Streptomyces sp.

Cheenpracha, Sarot and Hui, Zhang and Mar, Annie M. N. and Adam, P. Foss and Hin, Foo Sek and Shin, Lai Ngit and Meng, Jee Jap and Fong, Seow Heng and Choke, H. Coy and Chee, Chang Leng (2009) Yeast glycogen synthase kinase-3β pathway inhibitors from an organic extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864

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Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2- hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2″-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-α-rhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3β assay. © 2009 American Chemical Society and American Society of Pharmacognosy.

Item Type: Article
Keyword: 2 amino n (2 (cyclohex 2'' enyl)acetyl)acetimide, 2 amino n 2' (phenylacetyl)propanimide, 3 [5 methyl 4 oxo 2 hydroxy 5 octenyl]glutarimide, 6 o methyl 7 o alpha rhamnopyranosyldaidzein, 7 o alpha levo rhamnopyranosyl daidzein, cycloheximide, glycogen synthase kinase 3beta, Imide, Isocycloheximide, Isoflavonoid, Unclassified drug, Carbon nuclear magnetic resonance, Drug structure, Heteronuclear multiple bond correlation, Heteronuclear multiple quantum coherence, Nonhuman, Nuclear Overhauser effect, Nucleotide sequence, Proton nuclear magnetic resonance, Streptomyces, Yeast Species Index: Streptomyces sp.
Subjects: Q Science > QR Microbiology > QR1-502 Microbiology > QR1-74.5 General
Department: SCHOOL > School of Science and Technology
Depositing User: ADMIN ADMIN
Date Deposited: 30 Mar 2011 09:36
Last Modified: 04 Apr 2011 15:28

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